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Myocardial Recovery and the Failing Heart: Medical, Device and Mechanical Methods

Authors:

Judith Z. Goldfinger ,

Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY
About Judith Z.
MD
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Ajith P. Nair

Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY
About Ajith P.
MD
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Abstract

Background

Cardiac remodeling describes the molecular, cellular, and interstitial changes that cause the ventricle to develop pathologic geometry as heart failure progresses. Reverse remodeling, or the healing of a failing heart, leads to improved mortality and quality of life.

Findings

Therapies that lead to reverse remodeling include medications such as β-blockers and angiotensin-converting enzyme inhibitors; cardiac resynchronization therapy with biventricular pacing; and mechanical support with left ventricular assist devices.

Conclusions

Further study is needed to better predict which patients will benefit most from these therapies and will then go on to experience reverse remodeling and myocardial recovery.

How to Cite: Goldfinger, J.Z. and Nair, A.P., 2014. Myocardial Recovery and the Failing Heart: Medical, Device and Mechanical Methods. Annals of Global Health, 80(1), pp.55–60. DOI: http://doi.org/10.1016/j.aogh.2013.12.006
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Published on 23 Apr 2014.
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