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Cardiovascular Pathophysiology in Chronic Kidney Disease: Opportunities to Transition from Disease to Health

Authors:

Matthew I. Tomey ,

Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY
About Matthew I.
MD
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Jonathan A. Winston

Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY
About Jonathan A.
MD
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Abstract

Background

Chronic kidney disease (CKD) is common, and is associated with a high burden of cardiovascular disease. This cardiovascular risk is incompletely explained by traditional risk factors, calling attention to a need to better understand the pathways in CKD contributing to adverse cardiovascular outcomes.

Findings

Pathophysiological derangements associated with CKD, including disordered sodium, potassium, and water homeostasis, renin-angiotensin-aldosterone and sympathetic activity, anemia, bone and mineral metabolism, uremia, and toxin accumulation may contribute directly to progression of cardiovascular disease and adverse outcomes.

Conclusion

Improving cardiovascular health in patients with CKD requires improved understanding of renocardiac pathophysiology. Ultimately, the most successful strategy may be prevention of incident CKD itself.

How to Cite: Tomey, M.I. and Winston, J.A., 2014. Cardiovascular Pathophysiology in Chronic Kidney Disease: Opportunities to Transition from Disease to Health. Annals of Global Health, 80(1), pp.69–79. DOI: http://doi.org/10.1016/j.aogh.2013.12.007
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Published on 23 Apr 2014.
Peer Reviewed

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