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Infection and Cancer: Global Distribution and Burden of Diseases

Authors:

Jin-Kyoung Oh ,

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden The Risk Appraisal and Prevention Branch, National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea
About Jin-Kyoung
PhD, MPH
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Elisabete Weiderpass

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Cancer Registry of Norway, Oslo, Norway, Department of Genetic Epidemiology, Folkhälsan Research Center, Helsinki, Finland, and Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
About Elisabete
PhD, MD
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Abstract

Background

Infection is one of the main risk factors for cancer.

Objectives

Epidemiology, pathogenesis, and disease burden of infection-related cancers were reviewed by infectious agents.

Findings

Chronic infection with Epstein-Barr virushepatitis B and C virusesKaposi sarcoma herpes virushuman immunodeficiency virus (HIV) type 1, human papillomavirus (HPV), human T-cell lymphotropic virus type 1, Helicobacter pyloriClonorchis sinensisOpisthorchis viverrini,and Schistosoma haematobium are associated with nasopharyngeal carcinomalymphomaand leukemia, including non-Hodgkin lymphomaHodgkin lymphoma, and Burkitt lymphomahepatocellular carcinoma; Kaposi sarcoma; oropharyngeal carcinoma; cervical carcinoma and carcinoma of other anogential sites; adult T-cell leukemia/lymphoma; gastric carcinoma; cholangiocarcinoma; and urinary bladder cancer. In 2008, approximately 2 million new cancer cases (16%) worldwide were attributable to infection. If these infections could be prevented and/or treated, it is estimated that there would be about 23% fewer cancers in less developed regions of the world, and about 7% fewer cancers in more developed regions.

Conclusion

Widespread application of existing public health methods for the prevention of infection, such as vaccination, safer injection practices, quality-assured screening of all donated blood and blood componentsantimicrobial treatments, and safer sex practices, including minimizing one’s lifetime number of sexual partners and condom use, could have a substantial effect on the future burden of cancer worldwide.

How to Cite: Oh, J.-K. and Weiderpass, E., 2014. Infection and Cancer: Global Distribution and Burden of Diseases. Annals of Global Health, 80(5), pp.384–392. DOI: http://doi.org/10.1016/j.aogh.2014.09.013
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Published on 13 Dec 2014.
Peer Reviewed

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