Start Submission Become a Reviewer

Reading: Global Variation of Human Papillomavirus Genotypes and Selected Genes Involved in Cervical M...

Download

A- A+
Alt. Display

Reviews

Global Variation of Human Papillomavirus Genotypes and Selected Genes Involved in Cervical Malignancies

Authors:

R.S. Akram Husain ,

Department of Genetics, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India
About R.S. Akram
MSc, MPhil
X close

V. Ramakrishnan

Department of Genetics, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India
About V.
PhD
X close

Abstract

Background

Carcinoma of the cervix is ranked second among the top 5 cancers affecting women globally. Parallel to other cancers, it is also a complex disease involving numerous factors such as human papillomavirus (HPV) infection followed by the activity of oncogenes and environmental factors. The incidence rate of the disease remains high in developing countries due to lack of awareness, followed by mass screening programs, various socioeconomic issues, and low usage of preventive vaccines. Over the past 3 decades, extensive research has taken place in cervical malignancy to elucidate the role of host genes in the pathogenesis of the disease, yet it remains one of the most prevalent diseases. It is imperative that recent genome-wide techniques be used to determine whether carcinogenesis of oncogenes is associated with cervical cancer at the molecular level and to translate that knowledge into developing diagnostic and therapeutic tools.

Objective

The aim of this study was to discuss HPV predominance with their genotype distribution worldwide, and in India, as well as to discuss the newly identified oncogenes related to cervical cancer in current scenario.

Findings

Using data from various databases and robust technologies, oncogenes associated with cervical malignancies were identified and are explained in concise manner.

Conclusion

Due to the advent of recent technologies, new candidate genes are explored and can be used as precise biomarkers for screening and developing drug targets.

How to Cite: Husain, R.S.A. and Ramakrishnan, V., 2016. Global Variation of Human Papillomavirus Genotypes and Selected Genes Involved in Cervical Malignancies. Annals of Global Health, 81(5), pp.675–683. DOI: http://doi.org/10.1016/j.aogh.2015.08.026
21
Views
12
Downloads
Published on 29 Mar 2016.
Peer Reviewed

Downloads

  • PDF (EN)

    comments powered by Disqus