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The Impact of Early-Life Exposure to Air-borne Environmental Insults on the Function of the Airway Epithelium in Asthma

Authors:

Kirsten Spann ,

School of Biomedical Sciences, Queensland University of Technology, Queensland, Australia
About Kirsten
PhD
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Natale Snape,

Children's Health Research Centre, University of Queensland, Queensland, Australia
About Natale
PhD
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Engin Baturcam,

Children's Health Research Centre, University of Queensland, Queensland, Australia
About Engin
BSc, MSc
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Emmanuelle Fantino

Children's Health Research Centre, University of Queensland, Queensland, Australia
About Emmanuelle
PhD
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Abstract

The airway epithelium is both a physical barrier protecting the airways from environmental insults and a significant component of the innate immune response. There is growing evidence that exposure of the airway epithelium to environmental insults in early life may lead to permanent changes in structure and function that underlie the development of asthma. Here we review the current published evidence concerning the link between asthma and epithelial damage within the airways and identify gaps in knowledge for future studies.
How to Cite: Spann, K., Snape, N., Baturcam, E. and Fantino, E., 2016. The Impact of Early-Life Exposure to Air-borne Environmental Insults on the Function of the Airway Epithelium in Asthma. Annals of Global Health, 82(1), pp.28–40. DOI: http://doi.org/10.1016/j.aogh.2016.01.007
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Published on 17 Jun 2016.
Peer Reviewed

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