Original Research
A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
Authors:
Jessica E. Laine ,
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC
About Jessica E.
MS
Rebecca C. Fry
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC
About Rebecca C.
PhD
Abstract
Background
Prenatal exposure to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential biological mechanisms that underlie these changes include, but are not limited to, changes to the epigenome.
Objective
The aim of the present study was to identify whether the expression of key genes, proteins, or both and their associated biological pathways are perturbed by compiling datasets from studies on prenatal arsenic exposure.
Methods
We compiled datasets from 12 studies that analyzed the relationship between prenatal iAs exposure and changes to the fetal epigenome (5-methyl cytosine), transcriptome (mRNA expression), and/or proteome (protein expression).
Conclusions
The identification of the common set of genes across numerous human cohorts suggests a conserved biological response to prenatal arsenic exposure. The genes/proteins and their associated pathways may be useful in future mechanistic investigations of iAs associated diseases.
How to Cite:
Laine, J.E. and Fry, R.C., 2016. A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure. Annals of Global Health, 82(1), pp.189–196. DOI: http://doi.org/10.1016/j.aogh.2016.01.015
Published on
17 Jun 2016.
Peer Reviewed
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